Phylogeny of central CO2/pH chemoreception in vertebrates
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HIGHLIGHTED TOPIC Central CO2 Chemoreception in Cardiorespiratory Control Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus
Mulkey DK, Wenker IC, Kréneisz O. Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus. J Appl Physiol 108: 1433–1439, 2010. First published January 21, 2010; doi:10.1152/japplphysiol.01240.2009.—Central chemoreception is the mechanism by which CO2/pH-sensitive neurons (i.e., chemoreceptors) regulate breathing in response to changes in tissue pH. A re...
متن کاملCurrent ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus.
Central chemoreception is the mechanism by which CO2/pH-sensitive neurons (i.e., chemoreceptors) regulate breathing in response to changes in tissue pH. A region of the brain stem called the retrotrapezoid nucleus (RTN) is thought to be an important site of chemoreception (23), and recent evidence suggests that RTN chemoreception involves two interrelated mechanisms: H+-mediated activation of p...
متن کاملHIGHLIGHTED TOPIC Central CO2 Chemoreception in Cardiorespiratory Control CO2 chemoreception in cardiorespiratory control
Putnam RW. CO2 chemoreception in cardiorespiratory control. J Appl Physiol 108: 1796–1802, 2010. First published January 21, 2010; doi:10.1152/japplphysiol.01169.2009.—Considerable progress has been made elucidating the cellular signals and ion channel targets involved in the response to increased CO2/H of brain stem neurons from chemosensitive regions. Intracellular pH (pHi) does not exhibit r...
متن کاملCentral CO2 chemoreception in cardiorespiratory control.
HYPERCAPNIA, largely through the direct influence of CO2 on proton production, but possibly also via a direct effect of molecular CO2, is the primary chemical stimulus for alveolar ventilation. Small deviations in arterial CO2 in either direction elicit integrated cardiorespiratory reflexes that quickly restore CO2 levels in various tissue and cellular compartments, thereby providing the body w...
متن کاملCommentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites CENTRAL CHEMORECEPTION IS A COMPLEX SYSTEM FUNCTION THAT INVOLVES MULTIPLE BRAIN SITES
TO THE EDITOR: Amniote vertebrates adjust the acid-base status of the blood through ventilatory alterations of PaCO2 and, to some degree, by renal modulation of bicarbonate concentration. Receptor systems for the ventilatory acid-base regulation has been studied mainly in mammals, in which the ventrolateral surface of the medulla oblongata that faces the cerebrospinal fluid of the forth ventric...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2001